Avion Baker's longest-running television role was on the first five seasons of HBO's True Blood as a younger version of Tara Thornton. She made a guest appearance on the Hannah Montana episode Debt It Be in 2006 and voiced Kayla on Disney's Special Agent Oso in the following year.
Baker can be heard on the soundtrack for the ER episode Believe the Unseen. In 2008, she joined the cast of The Backyardigans. She provided Uniqua's singing voice for twenty episodes, in addition to the Mega Music Fest 2010 special. Her final appearance on a Nickelodeon production was at the twenty-third annual Kid's Choice Awards in 2010.